Realistic modeling of entorhinal cortex field potentials and interpretation of epileptic activity in the guinea pig isolated brain preparation.

Pig Isolated Brain Preparation and Interpretation of Epileptic Activity in the Guinea Realistic Modeling of Entorhinal Cortex Field Potentials

Modeling of entorhinal cortex epileptic activity 1 Submitted to the Journal of Neurophysiology Revised version Realistic modeling of Entorhinal Cortex field potentials and interpretation of epileptic activity in the guinea-pig isolated brain preparation

246 words) Mechanisms underlying epileptic activities recorded from entorhinal cortex (EC) were studied through a computational model based on review of cytoarchitectonic and neurobiological data about this structure. The purpose of this study is to describe and use this model to interpret epileptiform discharge patterns recorded in an experimental model of ictogenesis (guinea-pig isolated brai...

Entorhinal Cortex field potentials and interpretation of epileptic activity in the guinea - pig isolated brain preparation

246 words) Mechanisms underlying epileptic activities recorded from entorhinal cortex (EC) were studied through a computational model based on review of cytoarchitectonic and neurobiological data about this structure. The purpose of this study is to describe and use this model to interpret epileptiform discharge patterns recorded in an experimental model of ictogenesis (guinea-pig isolated brai...

Slow periodic events and their transition to gamma oscillations in the entorhinal cortex of the isolated Guinea pig brain.

Slow (<1 Hz) periodic activity is a distinctive discharge pattern observed in different cortical and sub-cortical structures during sleep and anesthesia. By performing field and cellular recordings, we demonstrated that slow periodic events (0.02-0.4 Hz) are spontaneously generated in the entorhinal cortex of the in vitro isolated whole brain of the guinea pig. These events were characterized b...

Role of the hippocampal-entorhinal loop in temporal lobe epilepsy: extra- and intracellular study in the isolated guinea pig brain in vitro.

This article introduces a new experimental paradigm for the study of temporal lobe epilepsy. This approach utilizes the isolated guinea pig brain in vitro preparation, which generates a pattern of hypersynchronous neuronal activity similar to the peculiar 8-30 Hz rhythm characterizing stereoelectroencephalographic hippocampal recordings in human temporal lobe epilepsy. The present report descri...